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Comprehensive UPSC Science and Tech Study Material

Organ Transplantation

Subject- Science

Definition

  • Organ transplantation is a life-saving way wherein a failing organ (kidney, liver, heart, lung) is replaced with a healthy organ from a living donor (e.g., kidney, partial liver) or a deceased donor (brain-dead or after cardiac demise) to repair feature in last-stage organ failure. Common transplants consist of the kidney, liver, coronary heart, lungs, pancreas, and intestines.

Status

  • India is the third country in the world after the USA and China, in terms of the total number of transplants completed in a year.
  • Growing Demand and Persistent Shortage: Of 1.8 lakh renal failure cases annually, only 6,000 transplants occur, with a donation rate under 1 per million versus a need for 65 per million.
  • Slow Growth in Donor Numbers: Donor numbers, along with living and deceased donors, grew modestly from 6,916 in 2014 to about 16,041 in 2022.
  • Regional Variations: Telangana, Tamil Nadu, Karnataka, Gujarat, and Maharashtra lead in deceased donors, even as Delhi-NCR, Tamil Nadu, Kerala, Maharashtra, and West Bengal record the maximum living donors.

Gaps in India’s Organ Transplantation Programme

  • Infrastructural Deficiencies: Many government hospitals lack dedicated infrastructure for organ retrieval and transplantation, and face a high shortage of ICU beds vital for keeping brain-stem dead (BSD) donors and post-operative care.
  • Shortage of Skilled Transplant Professionals: Government hospitals face a crucial shortage of skilled transplant surgeons, nephrologists, urologists, anaesthetists, neurologists, neurosurgeons, and intensivists.
  • Procedural Bottlenecks: Delays in approval and formation of Brain-Stem Dead (BSD) Committees, vital for deceased organ donation, remain a prime hurdle.
  • Financial Strain: Insufficient investment blocks the initiation or revival of specialised programmes like lung transplantation, while the high value of immunosuppressant capsules imposes a heavy burden, as most schemes cover most effectively the first year of medication.
  • Peri-Transplant Donor Tissue Damage: Aging and sicknesses lessen donor organs, leading to Ischemia-Reperfusion Injury (IRI). Many organs are discarded due to inferior quality, impacting transplant achievement prices.
  • Chronic Rejection in Organ Transplantation: Long-term survival rates for transplanted organs have not appreciably improved during the last 20 years. Current anti-rejection treatment plans continue to be in large part unchanged, with only modest enhancements in survival rates.
  • Access and Awareness Gaps: India’s organ transplantation programme is challenged by the dominance of the private sector, limiting low-priced access for poor sufferers; the absence of green corridors hampers fast organ shipping; and low awareness, in conjunction with misconceptions about organ donation, discourage public participation.
  • Ethical and Legal Challenges: Organ trafficking, commercialisation of organ donation, and a black market for organs persist regardless of strict laws like the Transplantation of Human Organs and Tissues Act, 1994 (THOT Act, 1994).

Strategies to Enhance the Organ Transplantation Framework in India

  • Enhancing Infrastructure: Upgrade ICU and transplant centers in government hospitals with devoted Transplant ICUs (TICUs) and operation theatres, undertake advanced maintenance technology like hypothermic/normothermic device perfusion, and standardize organ procurement and delivery protocols to reduce delays and wastage.
  • Financial Support and Policy Reforms: Include liver and heart transplants under Ayushman Bharat, covering lifelong immunosuppressant expenses, along with elevated funding for transplant applications in government hospitals, in particular for luxurious processes like lung transplants.
  • Addressing Manpower Shortages: Adopt recruitment and retention policies for transplant experts (including surgeons, nephrologists, intensivists) and reduce common transfers to ensure program continuity.
  • Promoting Research and Ethical Practices: Invest in bioengineered organs, xenotransplantation, and AI-driven organ matching, at the same time as growing ethical guidelines for equitable organ allocation and obvious consent techniques.
  • Emphasising Broader Benefits: A robust organ and tissue transplant ecosystem can enhance medical tourism, enhance India’s soft power, promote inter-state coordination through efficient sharing networks, and support the health finances by generating revenue and lowering long-term healthcare expenses.

Strengthening Public Awareness: Launch national awareness campaigns using social media, TV, and superstar endorsements, at the side of school and college education, community engagement with survivor and donor family testimonials, and partnerships with spiritual leaders to promote organ donation and dispel myths.

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